At least six people have been killed after being caught in an avalanche sparked by the collapse of a glacier in the northern Italian Alps.
Emergency officials said nine others were injured in the collapse, with two people suffering serious injuries.
Rescue teams using helicopters and drones have been working through the night searching for 19 still missing.
Video of the incident showed an ice mass collapsing down the slopes of Marmolada, the area's highest mountain.
"An avalanche of snow, ice and rock which in its path hit the access road when there were several roped parties, some of which were swept away," emergency services spokeswoman Michela Canova said. "The definitive number of mountaineers involved is not yet known," she added.
The injured hikers, including one person left in critical condition, were taken to several hospitals around the area, rescue officials said.
It isn't immediately clear what caused the section of the glacier, called a serac, to collapse.
But Walter Milan, a rescue service spokesperson, told state TV the area has been experiencing unusually high temperatures in recent days.
"The heat is unusual,'' Mr Milan said, noting temperatures have reached 10C at the glacier's peak in recent days.
"That's extreme heat," he said. "Clearly it's something abnormal."
Reinhold Messner, an Italian mountaineer, told La Repubblica newspaper the glacier has been receding for several years due to the impact of global warming.
"There is hardly any ice left," Mr Messner said. He noted glaciers occasionally collapse "due to gravity," but said the reason for the glacier's retreat "is the global heat, which causes glaciers to melt".
We don't yet know what caused the catastrophic collapse of the Marmolada glacier, but it seems almost certain that climate change will have played a role.
The climate of the Alps is changing rapidly. Temperatures are reckoned to have increased by around 2C - twice the global average.
That's driving the retreat of the glaciers of the Alps. They are estimated to have lost half their ice volume since 1850 and loss rates have accelerated strongly since the late 1980s.
As glaciers recede, they can become unstable and threaten the people below them, particularly high elevation glaciers like the Marmolada which are often on steep slopes and rely on sub-zero temperatures to keep them locked in place.
As a result, catastrophic glacier collapses are becoming more frequent, says Paul Christoffersen, a professor of glaciology at the University of Cambridge.
The shifting ice of the high Alps shows once again how climate change is altering our landscape and hazards in ways scientists are still trying to understand.